1 of 5 | Green Bay Packers running back Josh Jacobs (R) is the No. 2 player in my Week 6 fantasy football rankings. File Photo by Tannen Maury/UPI | License Photo
Saquon Barkley and Josh Jacobs lead my Top-50 fantasy football running back rankings for Week 6 of the 2025 season.
Jonathan Taylor, Bijan Robinson and Jahmyr Gibbs join Barkley and Jacobs inside my Top 5. Kyren Williams, Christian McCaffrey, De’Von Achane, Ashton Jeanty and James Cook are my other Top-10 options.
My Top-50 wide receiver rankings for Week 6 can be found here. My waiver-wire and free agent targets for Week 6 are available here.
All of my positional rankings will be updated until Week 6 kickoffs. Players also will be moved out of or adjusted within the rankings based on injuries. Omarion Hampton, who is ruled out, should be removed from starting lineups.
Be sure to monitor your lineups for injury developments. Players from the Minnesota Vikings and Houston Texans, who are on bye, should not be in starting lineups.
Week 6 running back rankings
1. Saquon Barkley, Philadelphia Eagles at NYG
2. Josh Jacobs, Green Bay Packers vs. CIN
3. Jonathan Taylor, Indianapolis Colts vs. ARI
4. Bijan Robinson, Atlanta Falcons vs. BUF
5. Jahmyr Gibbs, Detroit Lions at KC
6. Kyren Williams, Los Angeles Rams at BAL
7. Christian McCaffrey, San Francisco 49ers at TB
8. De’Von Achane, Miami Dolphins vs. LAC
9. Ashton Jeanty, Las Vegas Raiders vs. TEN
10. James Cook, Buffalo Bills at ATL
11. Jacory Croskey-Merritt, Washington Commanders vs. CHI
12. Javonte Williams, Dallas Cowboys at CAR
13. Breece Hall, New York Jets vs. DEN
14. Rachaad White, Tampa Bay Buccaneers vs. SF
15. J.K. Dobbins, Denver Broncos vs. NYJ
16. Rico Dowdle, Carolina Panthers vs. DAL
17. Kenneth Walker, Seattle Seahawks at JAX
18. Quinshon Judkins, Cleveland Browns at PIT
19. Travis Etienne, Jacksonville Jaguars vs. SEA
20. Tony Pollard, Tennessee Titans at LV
21. D’Andre Swift, Chicago Bears at WAS
22. David Montgomery, Detroit Lions at KC
23. Alvin Kamara, New Orleans Saints vs. NE
24. Derrick Henry, Baltimore Ravens vs. LAR
25. Rhamondre Stevenson, New England Patriots at NO
26. Chase Brown, Cincinnati Bengals at GB
27. Jaylen Warren, Pittsburgh Steelers vs. CLE
28. Hassan Haskins, Los Angeles Chargers at MIA
29. R.J. Harvey, Denver Broncos vs. NYJ
30. Cam Skattebo, New York Giants vs. PHI
31. Kareem Hunt, Kansas City Chiefs vs. DET
32. Michael Carter, Arizona Cardinals at IND
33. Zach Charbonnet, Seattle Seahawks at JAX
34. Tyrone Tracy Jr., New York Giants vs. PHI
35. TreVeyon Henderson, New England Patriots at NO
36. Kimani Vidal, Los Angeles Chargers at MIA
37. Kenneth Gainwell, Pittsburgh Steelers vs. CLE
39. Kendre Miller, New Orleans Saints vs. NE
39. Emari Demercado, Arizona Cardinals at IND
40. Blake Corum, Los Angeles Rams at BAL
41. Justice Hill, Baltimore Ravens vs. LAR
42. Isiah Pacheco, Kansas City Chiefs vs. DET
43. Trevor Etienne, Carolina Panthers vs. DAL
44. Tyler Allgeier, Atlanta Falcons vs. BUF
45. Bhayshul Tuten, Jacksonville Jaguars vs. SEA
46. Ollie Gordon II, Miami Dolphins vs. LAC
47. Isaiah Davis, New York Jets vs. DEN
48. Jerome Ford, Cleveland Browns at PIT
49. Tyjae Spears, Tennessee Titans at LV
50. Brashard Smith, Kansas City Chiefs vs. DET
NFL: Jacksonville Jaguars defeat Kansas City Chiefs
Jacksonville Jaguars quarterback Trevor Lawrence celebrates after scoring a touchdown with under a minute remaining against the Kansas City Chiefs at EverBank Stadium in Jacksonville on October 6, 2025. Jacksonville defeated Kansas City 31-28. Photo by Joe Marino/UPI | License Photo
